Title : Synergistic protective effect of folic acid and vitamin B12 against nicotine-induced oxidative stress and apoptosis in pancreatic islets of the rat.

Pub. Date : 2016

PMID : 25973643






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1 Moreover, folic acid in combination with vitamin B12 also attenuated the nicotine-induced changes in markers of oxidative stress (17-88% recovery), TNF-alpha (40-99% recovery), and IL-6 level (47-65% recovery), CRP level (59-73% recovery), expression of NF-kappaB and caspase-3, and apoptosis in pancreatic islet cells. Nicotine interleukin 6 Rattus norvegicus