Pub. Date : 2015 Apr
PMID : 25973238
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin. | Cisplatin | sirtuin 1 | Homo sapiens |
| 2 | This study was designed to explore the relationship between SIRT1 expression and resistance of esophageal squamous cell carcinoma (ESCC) cells to cisplatin and reveal the underlying mechanism. | Cisplatin | sirtuin 1 | Homo sapiens |
| 3 | The influence of SIRT1 silence on sensitivity of ECa9706-CisR cells to cisplatin was confirmed using CCK-8 assay and flow cytometry. | Cisplatin | sirtuin 1 | Homo sapiens |
| 4 | Cisplatin 5 microM could cause proliferation inhibition, G2/M phase arrest and apoptosis in ECa9706-CisR cells and these effects could be enhanced dramatically by SIRT1 silencing. | Cisplatin | sirtuin 1 | Homo sapiens |
| 5 | CONCLUSIONS: Over-expression of SIRT1 may cause resistance of ESCC cells to cisplatin through the mechanism involved with Noxa expression. | Cisplatin | sirtuin 1 | Homo sapiens |