Pub. Date : 2015 Aug 1
PMID : 25972510
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aberrant glomerular filtration of urokinase-type plasminogen activator in nephrotic syndrome leads to amiloride-sensitive plasminogen activation in urine. | Amiloride | plasminogen activator, urokinase | Homo sapiens |
| 2 | The ENaC blocker amiloride is an off-target inhibitor of urokinase-type plasminogen activator (uPA) in vitro. | Amiloride | plasminogen activator, urokinase | Homo sapiens |
| 3 | The ENaC blocker amiloride is an off-target inhibitor of urokinase-type plasminogen activator (uPA) in vitro. | Amiloride | plasminogen activator, urokinase | Homo sapiens |
| 4 | It was hypothesized that uPA is abnormally filtered to preurine and is inhibited in urine by amiloride in nephrotic syndrome. | Amiloride | plasminogen activator, urokinase | Homo sapiens |
| 5 | Amiloride inhibits urine uPA activity which attenuates plasminogen activation and urine protease activity in vivo. | Amiloride | plasminogen activator, urokinase | Homo sapiens |
| 6 | Urine uPA is a relevant target for amiloride in vivo. | Amiloride | plasminogen activator, urokinase | Homo sapiens |