Title : Sesquiterpene lactone parthenolide attenuates production of inflammatory mediators by suppressing the Toll-like receptor-4-mediated activation of the Akt, mTOR, and NF-κB pathways.

Pub. Date : 2015 Sep

PMID : 25971793






4 Functional Relationships(s)
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1 Sesquiterpene lactone parthenolide attenuates production of inflammatory mediators by suppressing the Toll-like receptor-4-mediated activation of the Akt, mTOR, and NF-kappaB pathways. parthenolide nuclear factor kappa B subunit 1 Homo sapiens
2 However, the effect of parthenolide on the Akt/mTOR and NF-kappaB pathway activation-induced productions of inflammatory mediators in keratinocytes has not been studied. parthenolide nuclear factor kappa B subunit 1 Homo sapiens
3 Using human keratinocytes, we investigated the effect of parthenolide on the inflammatory mediator production in relation to the Toll-like receptor-4-mediated-Akt/mTOR and NF-kappaB pathways, which regulate the transcription genes involved in immune and inflammatory responses. parthenolide nuclear factor kappa B subunit 1 Homo sapiens
4 The results show that parthenolide appears to attenuate the lipopolysaccharide-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor-4-mediated activation of the Akt, mTOR, and NF-kappaB pathways. parthenolide nuclear factor kappa B subunit 1 Homo sapiens