Title : Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C.

Pub. Date : 2015 May 15

PMID : 25971429






2 Functional Relationships(s)
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1 Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-kappaB/p65 and MUC1-C. BACKGROUND: Prostate cancer is one of the most common malignancies in men. Curcumin mitogen-activated protein kinase kinase 7 Homo sapiens
2 In addition, curcumin reduced the protein expression of MUC1-C and NF-kappaB subunit p65, which were abrogated in the presence of the inhibitors of MEK/ERK1/2 (PD98059) and SAPK/JNK (SP60015). Curcumin mitogen-activated protein kinase kinase 7 Homo sapiens