Pub. Date : 2015 Jun 7
PMID : 25963854
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The mechanism of hTopI is specifically targeted in cancer treatment using camptothecin derivatives. | Camptothecin | DNA topoisomerase I | Homo sapiens |
2 | These drugs convert the hTopI activity into a cellular poison, and hence the cytotoxic effects of camptothecin derivatives correlate with the hTopI activity. | Camptothecin | DNA topoisomerase I | Homo sapiens |
3 | These drugs convert the hTopI activity into a cellular poison, and hence the cytotoxic effects of camptothecin derivatives correlate with the hTopI activity. | Camptothecin | DNA topoisomerase I | Homo sapiens |
4 | Here we demonstrate potential applications of a fluorophore-quencher based DNA sensor designed for measurement of hTopI cleavage-ligation activities, which are the catalytic steps affected by camptothecin. | Camptothecin | DNA topoisomerase I | Homo sapiens |