Pub. Date : 2015 May 7
PMID : 25961164
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol Protects against Antimycin A-Induced Insulin Resistance in Human Skeletal Muscle Cells. | celastrol | insulin | Homo sapiens |
| 2 | The aim of the present study was to evaluate the functional roles of an anti-inflammatory compound, celastrol, in mitochondrial dysfunction and insulin resistance induced by antimycin A (AMA) in human skeletal muscle cells. | celastrol | insulin | Homo sapiens |
| 3 | We found that celastrol treatment improved insulin-stimulated glucose uptake activity of AMA-treated cells, apparently via PI3K/Akt pathways, with significant enhancement of mitochondrial activities. | celastrol | insulin | Homo sapiens |
| 4 | Celastrol significantly increased protein phosphorylation of insulin signaling cascades with amplified expression of AMPK protein and attenuated NF-kappaB and PKC theta activation in human skeletal muscle treated with AMA. | celastrol | insulin | Homo sapiens |
| 5 | The improvement of insulin signaling pathways by celastrol was also accompanied by augmented GLUT4 protein expression. | celastrol | insulin | Homo sapiens |
| 6 | Taken together, these results suggest that celastrol may be advocated for use as a potential therapeutic molecule to protect against mitochondrial dysfunction-induced insulin resistance in human skeletal muscle cells. | celastrol | insulin | Homo sapiens |