Title : Stress-related and homeostatic cytokines regulate Vγ9Vδ2 T-cell surveillance of mevalonate metabolism.

Pub. Date : 2014

PMID : 25960933






2 Functional Relationships(s)
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1 We show here that Vgamma9Vdelta2 T cells pretreated with the stress-related, inflammasome-dependent cytokine interleukin 18 (IL-18) were potently activated not only by IPP but also by all downstream isoprenoid pyrophosphates that exhibit combined features of antigens and cell-extrinsic metabolic cues. isoprenoid pyrophosphates interleukin 18 Homo sapiens
2 We show here that Vgamma9Vdelta2 T cells pretreated with the stress-related, inflammasome-dependent cytokine interleukin 18 (IL-18) were potently activated not only by IPP but also by all downstream isoprenoid pyrophosphates that exhibit combined features of antigens and cell-extrinsic metabolic cues. isoprenoid pyrophosphates interleukin 18 Homo sapiens