Protein Name interleukin 18
Organism Homo sapiens
Gene ID 3606
Gene Symbol


UniProt Q14116 (IL18_HUMAN), A0A024R3E0 (A0A024R3E0_HUMAN)
Relationships Total Number of functionally related compound(s) : 686
Total Number of Articles : 953

interleukin 18

Gene Summary

The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020]

  • interleukin-18
  • IFN-gamma-inducing factor
  • IL-1 gamma
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