Title : TNF-α Producing Innate Lymphoid Cells (ILCs) Are Increased in Active Celiac Disease and Contribute to Promote Intestinal Atrophy in Mice.

Pub. Date : 2015

PMID : 25950701






2 Functional Relationships(s)
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1 RAG1-deficient mice given poly I:C exhibited increased frequency of TNF-alpha but not IFN-gamma/IL17A-producing ILCs in the gut and depletion of ILCs prevented the poly I:C-driven intestinal damage. Poly I-C tumor necrosis factor Mus musculus
2 Moreover, ILCs express TLR3 and are functionally able to respond to poly I:C with increased synthesis of TNF-alpha thus contributing to small intestinal atrophy. Poly I-C tumor necrosis factor Mus musculus