Title : Value of caffeic acid phenethyl ester pretreatment in experimental sepsis model in rats.

Pub. Date : 2015

PMID : 25948886






4 Functional Relationships(s)
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1 BACKGROUND AND AIM: The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. caffeic acid phenethyl ester tumor necrosis factor Rattus norvegicus
2 BACKGROUND AND AIM: The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. caffeic acid phenethyl ester tumor necrosis factor Rattus norvegicus
3 RESULTS: Pretreatment with CAPE decreased ET-1, TNF-alpha, and MDA levels in sepsis induced rats. caffeic acid phenethyl ester tumor necrosis factor Rattus norvegicus
4 CONCLUSION: Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models. caffeic acid phenethyl ester tumor necrosis factor Rattus norvegicus