Pub. Date : 2015 Jul 3
PMID : 25944899
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | c-Abl and HIPK2 synergized in activating p53 on apoptotic promoters in a reporter assay, and c-Abl was required for endogenous HIPK2 accumulation and phosphorylation of p53 at Ser(46) in response to DNA damage by gamma- and UV radiation. | Serine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | c-Abl and HIPK2 synergized in activating p53 on apoptotic promoters in a reporter assay, and c-Abl was required for endogenous HIPK2 accumulation and phosphorylation of p53 at Ser(46) in response to DNA damage by gamma- and UV radiation. | Serine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | These data demonstrate a new mechanism for the induction of DNA damage-induced apoptosis by c-Abl and illustrate network interactions between serine/threonine and tyrosine kinases that dictate cell fate. | Serine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |