Pub. Date : 2015
PMID : 25941817
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further investigating into the mechanisms, we found that celastrol treatment downregulated the activation of spleen tyrosine kinase (SYK) and the concomitant phosphorylation of mitogen-activated protein kinase kinase (MAPKK/MEK), extracellular-signal-regulated kinase (ERK), and NFkappaB inhibitor alpha (IkappaBalpha), as well as citrullination of histones. | celastrol | mitogen-activated protein kinase kinase 7 | Homo sapiens |
| 2 | Our data reveals that celastrol potently inhibits neutrophil oxidative burst and NET formation induced by different inflammatory stimuli, possibly through downregulating the SYK-MEK-ERK-NFkappaB signaling cascade. | celastrol | mitogen-activated protein kinase kinase 7 | Homo sapiens |