Title : GCDCA down-regulates gene expression by increasing Sp1 binding to the NOS-3 promoter in an oxidative stress dependent manner.

Pub. Date : 2015 Jul 1

PMID : 25931146






1 Functional Relationships(s)
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1 In the human hepatocarcinoma cell line HepG2, cytotoxic response to GCDCA was characterized by the reduced activity of the respiratory complexes II+III, the increased expression and activation of the transcription factor Sp1, and a higher binding capacity of this at positions -1386, -632 and -104 of the NOS-3 promoter (pNOS-3). Glycochenodeoxycholic Acid nitric oxide synthase 3 Homo sapiens