Title : The effect of dexmedetomidine on inflammatory response of septic rats.

Pub. Date : 2015 May 1

PMID : 25929655






1 Functional Relationships(s)
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1 RESULTS: Compared with CLP group, dexmedetomidine significantly decreased not only the production of TNF-alpha and IL-6 both in plasma and BALF, but also inhibited the expression of TLR4 and MyD88 in mRNA level and the activation of ERK1/2 and NF-kappaB in the lung tissues of CLP-induced septic rats. Dexmedetomidine mitogen activated protein kinase 3 Rattus norvegicus