Pub. Date : 2015 Jul 1
PMID : 25929520
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It is generally accepted that Friedreich"s ataxia (FRDA) is caused by a deficiency in frataxin expression, a mitochondrial protein involved in iron homeostasis, which mainly affects the brain, dorsal root ganglia of the spinal cord, heart and in certain cases the pancreas. | Iron | frataxin | Homo sapiens |
| 2 | It is generally accepted that Friedreich"s ataxia (FRDA) is caused by a deficiency in frataxin expression, a mitochondrial protein involved in iron homeostasis, which mainly affects the brain, dorsal root ganglia of the spinal cord, heart and in certain cases the pancreas. | Iron | frataxin | Homo sapiens |
| 3 | In conclusion, our data show that FRDA cells present altered expression of genes related to cell cycle, oxidative stress and iron homeostasis which may be implicated in the increased apoptotic levels. | Iron | frataxin | Homo sapiens |