Title : Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's disease.

Pub. Date : 2015

PMID : 25923432






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The method is based on our previous findings that the production of Abeta from the interaction between the beta-amyloid precursor protein (APP) and Presenilin (PS), as part of the gamma-secretase complex, in cell culture is largely inhibited if the entire water-soluble NH2-terminal domain of PS is first added to the culture. Water amyloid beta (A4) precursor protein Mus musculus
2 The method is based on our previous findings that the production of Abeta from the interaction between the beta-amyloid precursor protein (APP) and Presenilin (PS), as part of the gamma-secretase complex, in cell culture is largely inhibited if the entire water-soluble NH2-terminal domain of PS is first added to the culture. Water amyloid beta (A4) precursor protein Mus musculus
3 Here we demonstrate that two small, non-overlapping water-soluble peptides from the PS-1 NH2-terminal domain can substantially and specifically inhibit the production of total Abeta as well as Abeta40 and 42 in vitro and in vivo in the brains of APP transgenic mice. Water amyloid beta (A4) precursor protein Mus musculus