Pub. Date : 2015 Jun
PMID : 25907295
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Itraconazole and clarithromycin inhibit P-glycoprotein activity in primary human sinonasal epithelial cells. | Itraconazole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Both itraconazole and clarithromycin have also been shown to have P-gp inhibitory properties in other tissues, suggesting a novel explanation for their immunomodulatory effects in CRS. | Itraconazole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | RESULTS: Both itraconazole and clarithromycin demonstrated a dose-response curve for P-gp inhibition similar to that of Zosuquidar. | Itraconazole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | CONCLUSION: Both itraconazole and clarithromycin are capable of inhibiting sinonasal epithelial cell associated P-gp. | Itraconazole | ATP binding cassette subfamily B member 1 | Homo sapiens |