Pub. Date : 2000
PMID : 25905342
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Type 1 familial glucocorticoid deficiency is the result of mutations of the MC2 receptor itself.ACTH stimulates cortisol synthesis and secretion by regulating multiple steps in the steroidogenetic pathway including an increase of the number of low-density lipoprotein (LDL) receptors and the cleavage of the side-chain of cholesterol converting it to pregnenolone, the first and rate-limiting step in cortisol production. | Pregnenolone | melanocortin 2 receptor | Homo sapiens |