Title : Purvalanol induces endoplasmic reticulum stress-mediated apoptosis and autophagy in a time-dependent manner in HCT116 colon cancer cells.

Pub. Date : 2015 Jun

PMID : 25901510






1 Functional Relationships(s)
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1 HCT 116 colon cancer cells were exposed to purvalanol, which activated ER stress via upregulation of PERK, IRE1alpha gene expression, eIF-2alpha phosphorylation and ATF-6 cleavage at early time-points in the HCT 116 colon cancer cells. purvalanol B eukaryotic translation initiation factor 2A Homo sapiens