Title : β2-microglobulin induces epithelial-mesenchymal transition in human renal proximal tubule epithelial cells in vitro.

Pub. Date : 2015 Apr 23

PMID : 25899529






3 Functional Relationships(s)
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Protein Name
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1 Excess beta2-M in the HK-2 cells led to a decrease in iron and an increase in hypoxia inducible factor-1alpha (HIF-1alpha), which induced EMT in the HK-2 cells. Iron beta-2-microglobulin Homo sapiens
2 CONCLUSION: These findings demonstrate that the activity of beta2-M is mediated by the beta2-M/HFE complex, which regulates intracellular iron homeostasis and HIF-1alpha and ultimately induces EMT in HK2 cells. Iron beta-2-microglobulin Homo sapiens
3 CONCLUSION: These findings demonstrate that the activity of beta2-M is mediated by the beta2-M/HFE complex, which regulates intracellular iron homeostasis and HIF-1alpha and ultimately induces EMT in HK2 cells. Iron beta-2-microglobulin Homo sapiens