Title : Catechol-O-methyltransferase Val158Met genotype and the clinical responses to duloxetine treatment or plasma levels of 3-methoxy-4-hydroxyphenylglycol and homovanillic acid in Japanese patients with major depressive disorder.

Pub. Date : 2015

PMID : 25897233






3 Functional Relationships(s)
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1 PURPOSE: This study investigated the relationships among the plasma levels of catecholamine metabolites, the clinical response to duloxetine treatment, and Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene. Duloxetine Hydrochloride catechol-O-methyltransferase Homo sapiens
2 PURPOSE: This study investigated the relationships among the plasma levels of catecholamine metabolites, the clinical response to duloxetine treatment, and Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene. Duloxetine Hydrochloride catechol-O-methyltransferase Homo sapiens
3 CONCLUSION: The relationship among the COMT Val158Met polymorphism, plasma levels of catecholamine metabolites, and responses to duloxetine is complex. Duloxetine Hydrochloride catechol-O-methyltransferase Homo sapiens