Pub. Date : 2015
PMID : 25896065
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High-mobility group box-1 (HMGB-1), an endogenous activator of TLR4, rapidly increased in TLR4 immunoprecipitates upon high glucose stimulation, and this association was reduced by N-acetylcysteine, an antioxidant. | Glucose | high mobility group box 1 | Homo sapiens |
| 2 | High-mobility group box-1 (HMGB-1), an endogenous activator of TLR4, rapidly increased in TLR4 immunoprecipitates upon high glucose stimulation, and this association was reduced by N-acetylcysteine, an antioxidant. | Glucose | high mobility group box 1 | Homo sapiens |
| 3 | An HMGB-1 inhibitor glycyrrhizin suppressed high glucose-induced Syk activation. | Glucose | high mobility group box 1 | Homo sapiens |
| 4 | High glucose induces an immediate, reactive oxygen species-dependent, extracellular release of HMGB-1 which binds to TLR4 and activates it, leading to Syk activation. | Glucose | high mobility group box 1 | Homo sapiens |