Title : [Study of structure-activity relationship in series of Gsb-106 analogues-dipeptide mimetics of brain-derived neurotrophic factor].

Pub. Date : 2014 Mar-Apr

PMID : 25895333






2 Functional Relationships(s)
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1 [Study of structure-activity relationship in series of Gsb-106 analogues-dipeptide mimetics of brain-derived neurotrophic factor]. Dipeptides brain-derived neurotrophic factor Rattus norvegicus
2 In previous work we have obtained a dimeric dipeptide mimetic of 4th loop of BDNF - hexamethylenediamide bis-(N-monosuccinil-L-seryl-L-lysine) (GSB-106), having a neuroprotective activity in vitro in a concentration range 10(-5)-10(-8) M and an antidepressant activity in vivo at doses 0.1 and 1 mg/kg i.p. Dipeptides brain-derived neurotrophic factor Rattus norvegicus