Title : The role of miR-125b-mitochondria-caspase-3 pathway in doxorubicin resistance and therapy in human breast cancer.

Pub. Date : 2015 Sep

PMID : 25894378






2 Functional Relationships(s)
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1 However, the overexpression of miR-125b did not influence the doxorubicin accumulation but downregulated the myeloid cell leukemia-1 (Mcl-1) levels, which may be the mechanism of apoptosis induction caused by doxorubicin combining with miR-125b in MCF-7/DR cells. Doxorubicin MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 However, the overexpression of miR-125b did not influence the doxorubicin accumulation but downregulated the myeloid cell leukemia-1 (Mcl-1) levels, which may be the mechanism of apoptosis induction caused by doxorubicin combining with miR-125b in MCF-7/DR cells. Doxorubicin MCL1 apoptosis regulator, BCL2 family member Homo sapiens