Pub. Date : 2015 Sep 10
PMID : 25891177
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Among these derivatives, bis[2-hydroxybenzylidene]acetone (BHBA) was one of the most potent Nrf2 inducers with minimal toxicity and improved pharmacological properties and was thus selected for further investigation. | bis(2-hydroxybenzylidene)acetone | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Among these derivatives, bis[2-hydroxybenzylidene]acetone (BHBA) was one of the most potent Nrf2 inducers with minimal toxicity and improved pharmacological properties and was thus selected for further investigation. | bis(2-hydroxybenzylidene)acetone | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | BHBA activated the Nrf2 pathway in the canonical Keap1-Cys151-dependent manner. | bis(2-hydroxybenzylidene)acetone | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | INNOVATION: The curcumin derivative, BHBA, is a potent inducer of Nrf2. | bis(2-hydroxybenzylidene)acetone | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | CONCLUSION: Taken together, our results demonstrate that BHBA, a curcumin analog with improved Nrf2-activating and chemopreventive activities both in vitro and in vivo, could be developed into a chemoprotective pharmacological agent. | bis(2-hydroxybenzylidene)acetone | NFE2 like bZIP transcription factor 2 | Homo sapiens |