Title : ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells.

Pub. Date : 2015 Mar 25

PMID : 25879940






1 Functional Relationships(s)
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1 NK cells treated with 8-Br-ADPR, an ADPR antagonist, as well as NK cells from Cd38(-/-) mice showed reduced tumor-induced granule polarization, degranulation, granzyme B secretion, and cytotoxicity of NK cells. 8-br-adpr granzyme B Mus musculus