Protein Name granzyme B
Organism Mus musculus
Gene ID 14939
Gene Symbol

Gzmb

UniProt P04187 (GRAB_MOUSE), Q3TZH4 (Q3TZH4_MOUSE)
Relationships Total Number of functionally related compound(s) : 142
Total Number of Articles : 141
Description

granzyme B

Gene Summary

This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Mice lacking a functional copy of this gene exhibit impaired immune cell-mediated cytolysis. [provided by RefSeq, Sep 2016]

synonyms
  • granzyme B(G,H)
  • cytotoxic cell protease 1
  • fragmentin-2
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Properties