Title : Dipeptidyl peptidase-4 inhibitor decreases abdominal aortic aneurysm formation through GLP-1-dependent monocytic activity in mice.

Pub. Date : 2015

PMID : 25876091






1 Functional Relationships(s)
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1 The results conclude that oral administration of sitagliptin can prevent abdominal aortic aneurysm formation in Ang II-infused apoE-/-mice, at least in part, by increasing of GLP-1 activity, decreasing MMP-2 and MMP-9 production from macrophage infiltration. Sitagliptin Phosphate matrix metallopeptidase 9 Mus musculus