Title : Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models.

Pub. Date : 2015 Jun 15

PMID : 25870145






2 Functional Relationships(s)
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Protein Name
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1 Compared with parental cells, a number of resistant cell populations were more sensitive to inhibition by the MEK inhibitor selumetinib (AZD6244; ARRY-142886) when treated in combination with the originating EGFR inhibitor. AZD 6244 epidermal growth factor receptor Homo sapiens
2 Compared with parental cells, a number of resistant cell populations were more sensitive to inhibition by the MEK inhibitor selumetinib (AZD6244; ARRY-142886) when treated in combination with the originating EGFR inhibitor. AZD 6244 epidermal growth factor receptor Homo sapiens