Pub. Date : 2015 Apr 13
PMID : 25867530
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Levosimendan displays anti-inflammatory effects and decreases MPO bioavailability in patients with severe heart failure. | Simendan | myeloperoxidase | Homo sapiens |
| 2 | We evaluated the effects of levosimendan-treatment on MPO in patients with acute decompensation of chronic heart failure over a one week course. | Simendan | myeloperoxidase | Homo sapiens |
| 3 | Plasma MPO levels were significantly decreased after levosimendan treatment (from 252.1 +- 31.1 pmol/l at baseline to 215.02 +- 27.96 pmol/l at 6 h, p < 0.05). | Simendan | myeloperoxidase | Homo sapiens |
| 4 | Ex vivo incubation of whole blood with levosimendan decreased MPO release after PMN-stimulation (8.2 +- 1.4-fold increase at baseline vs. 6.0 +- 1.1-fold increase with levosimendan). | Simendan | myeloperoxidase | Homo sapiens |
| 5 | We here provide the first evidence that levosimendan treatment inhibits MPO release by PMNs in decompensated heart failure patients. | Simendan | myeloperoxidase | Homo sapiens |