Title : Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737.

Pub. Date : 2015 Jul

PMID : 25862283






1 Functional Relationships(s)
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1 Interestingly, cells overexpressing Bcl-xL were more sensitive to apoptosis upon treatment with the BH3-mimetic ABT-737, suggesting that despite its role in Bax inhibition, Bcl-xL also primes mitochondria to permeabilization and cytochrome c release. BH 3 BCL2-associated X protein Mus musculus