Title : Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities.

Pub. Date : 2016 May

PMID : 25850408






1 Functional Relationships(s)
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1 RESULTS: In endothelial cells, 0.1-10 mumol/L resveratrol suppressed IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB phosphorylation, as well as tumor necrosis factor-alpha and interleukin-6 production, and restored the insulin receptor substrate-1 (Irs-1)/Akt/endothelial NO synthase signaling pathway. Resveratrol AKT serine/threonine kinase 1 Rattus norvegicus