Title : Prediction of in vivo clearance and associated variability of CYP2C19 substrates by genotypes in populations utilizing a pharmacogenetics-based mechanistic model.

Pub. Date : 2015 Jun

PMID : 25845826






1 Functional Relationships(s)
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1 These data were then used in mechanistic models to predict genotype-dependent disposition of CYP2C19 substrates (i.e., S-mephenytoin, citalopram, pantoprazole, and voriconazole) by incorporating in vivo clearance or pharmacokinetics of wild-type subjects and parameters of other clearance pathways. Mephenytoin cytochrome P450 family 2 subfamily C member 19 Homo sapiens