Title : Spectroscopic and computational studies of cobalamin species with variable lower axial ligation: implications for the mechanism of Co-C bond activation by class I cobalamin-dependent isomerases.

Pub. Date : 2015 Apr 20

PMID : 25839944






1 Functional Relationships(s)
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1 Collectively, our results indicate that a reduction in the basicity of the lower axial ligand causes changes to the cofactor"s electronic structure in the Co(II) state that replicate the effects seen upon binding of Co(II)Cbl to Class I isomerases, which replace the lower axial dimethylbenzimidazole ligand of AdoCbl with a protein-derived histidine (His) residue. 5,6-dimethylbenzimidazole mitochondrially encoded cytochrome c oxidase II Homo sapiens