Pub. Date : 2015 Aug
PMID : 25832589
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | After 20-muM thioridazine treatment for 24 h, the protein level of DRD2 in SiHa cells was analyzed by Western blots, apoptosis was detected with the phosphatidylserine externalization and comet assay, and necrosis was detected by measuring high-mobility group box 1 protein (HMGB1). | Thioridazine | dopamine receptor D2 | Homo sapiens |
| 2 | Dopamine D2 receptor blocker thioridazine induces cell death in human uterine cervical carcinoma cell line SiHa. | Thioridazine | dopamine receptor D2 | Homo sapiens |
| 3 | AIM: The aim of this study was to explore the correlation of dopamine D2 receptor (DRD2) and the development of uterine cervical cancer, and the effect of thioridazine (an antagonist of DRD2) on the SiHa cell line. | Thioridazine | dopamine receptor D2 | Homo sapiens |
| 4 | In vitro, DRD2 blocker thioridazine treatment resulted in death of SiHa cells with the expression of DRD2 significantly regulated down (P < 0.05), and thioridazine significantly induced SiHa apoptosis (P = 0.016) and necrosis (P < 0.01). | Thioridazine | dopamine receptor D2 | Homo sapiens |
| 5 | In vitro, DRD2 blocker thioridazine treatment resulted in death of SiHa cells with the expression of DRD2 significantly regulated down (P < 0.05), and thioridazine significantly induced SiHa apoptosis (P = 0.016) and necrosis (P < 0.01). | Thioridazine | dopamine receptor D2 | Homo sapiens |
| 6 | In vitro, DRD2 blocker thioridazine treatment resulted in death of SiHa cells with the expression of DRD2 significantly regulated down (P < 0.05), and thioridazine significantly induced SiHa apoptosis (P = 0.016) and necrosis (P < 0.01). | Thioridazine | dopamine receptor D2 | Homo sapiens |