Pub. Date : 2015
PMID : 25815345
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PGE2-induced IDO1 inhibits the capacity of fully mature DCs to elicit an in vitro antileukemic immune response. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 2 | In particular, the role of IDO1 expression in PGE2-matured Mo-DCs has been addressed. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 3 | Here we show that PGE2, which is required for full maturation of DCs, is one mediator of DC tolerance by enhancing IDO1. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 4 | PGE2-mediated expression of IDO1 results in the production of kynurenine, in the generation of Tregs, and in the inhibition of either the allogeneic or the autologous antigen-specific stimulatory capacity of DCs. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 5 | When pulsed with leukemic lysates and matured with PGE2, DCs are impaired in the induction of IFN-gamma secreting CD4(+) and CD8(+) T cells due to IDO1 upregulation. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 6 | Overall, these results point toward the use of IDO1 inhibitors to enhance the vaccination capacity of DCs, matured with PGE2. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |