Title : Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling.

Pub. Date : 2015 Jul

PMID : 25813876






1 Functional Relationships(s)
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1 alpha-Syn overexpression also inhibited PP2A activity, while the PP2A agonist C2 ceramide suppressed both S6K1 activation and IRS-1 Ser636 phosphorylation upon alpha-Syn overexpression. N-acetylsphingosine ribosomal protein S6 kinase B1 Homo sapiens