Title : Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling.

Pub. Date : 2015 Jul

PMID : 25813876






1 Functional Relationships(s)
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1 In this study, we found an increase in IRS-1 phosphorylation at Ser636 and decrease in tyrosine phosphorylation, which accelerated IRS-1 turnover and reduced insulin-Akt signaling in alpha-Syn-overexpressing SK-N-SH cells and transgenic mice. Tyrosine AKT serine/threonine kinase 1 Homo sapiens