PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25813876-5 2015 In this study, we found an increase in IRS-1 phosphorylation at Ser636 and decrease in tyrosine phosphorylation, which accelerated IRS-1 turnover and reduced insulin-Akt signaling in alpha-Syn-overexpressing SK-N-SH cells and transgenic mice. Tyrosine 87-95 AKT serine/threonine kinase 1 Homo sapiens 166-169