Title : The 4'-hydroxyl group of resveratrol is functionally important for direct activation of PPARα.

Pub. Date : 2015

PMID : 25798826






4 Functional Relationships(s)
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1 The 4"-hydroxyl group of resveratrol is functionally important for direct activation of PPARalpha. 4"-hydroxyl peroxisome proliferator activated receptor alpha Mus musculus
2 The results of experiments using the crystal structure of the PPARalpha ligand-binding domain and an analysis of the activation of PPARalpha by a resveratrol analog 4-phenylazophenol (4-PAP) in vivo indicate that the 4"-hydroxyl group of resveratrol is critical for the direct activation of PPARalpha. 4"-hydroxyl peroxisome proliferator activated receptor alpha Mus musculus
3 The results of experiments using the crystal structure of the PPARalpha ligand-binding domain and an analysis of the activation of PPARalpha by a resveratrol analog 4-phenylazophenol (4-PAP) in vivo indicate that the 4"-hydroxyl group of resveratrol is critical for the direct activation of PPARalpha. 4"-hydroxyl peroxisome proliferator activated receptor alpha Mus musculus
4 The results of experiments using the crystal structure of the PPARalpha ligand-binding domain and an analysis of the activation of PPARalpha by a resveratrol analog 4-phenylazophenol (4-PAP) in vivo indicate that the 4"-hydroxyl group of resveratrol is critical for the direct activation of PPARalpha. 4"-hydroxyl peroxisome proliferator activated receptor alpha Mus musculus