Title : Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice.

Pub. Date : 2015 May

PMID : 25796567






3 Functional Relationships(s)
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1 Endocannabinoids, including 2-arachidonoylglycerol (2-AG), activate presynaptic cannabinoid type 1 receptors (CB1R) on inhibitory and excitatory neurons, resulting in a decreased release of neurotransmitters. Endocannabinoids cannabinoid receptor 1 (brain) Mus musculus
2 Endocannabinoids, including 2-arachidonoylglycerol (2-AG), activate presynaptic cannabinoid type 1 receptors (CB1R) on inhibitory and excitatory neurons, resulting in a decreased release of neurotransmitters. Endocannabinoids cannabinoid receptor 1 (brain) Mus musculus
3 The event-specific activation of the endocannabinoid system by inhibition of the endocannabinoid degrading enzymes may offer a promising strategy to selectively activate CB1Rs at the site of excessive neuronal activation with the overall goal to prevent the development epilepsy. Endocannabinoids cannabinoid receptor 1 (brain) Mus musculus