Title : Induction of UDP-glucuronosyltransferase 2B15 gene expression by the major active metabolites of tamoxifen, 4-hydroxytamoxifen and endoxifen, in breast cancer cells.

Pub. Date : 2015 Jun

PMID : 25795461






1 Functional Relationships(s)
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1 In the present study, we show that this ERalpha-mediated upregulation was significantly reduced by two ER antagonists (fulvestrant and raloxifene) but was not affected by a third ER antagonist, 4-hydroxytamoxifen (4-OHTAM), a major active tamoxifen (TAM) metabolite. Raloxifene Hydrochloride estrogen receptor 1 Homo sapiens