Pub. Date : 2015
PMID : 25791399
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: CCND1, c-Fos and c-Jun mRNA levels were all significantly increased by treatment with progesterone in QGP-1 cells with PRB expression compared with PRA-transfected cells (p = 0.02, p = 0.007 and p = 0.001, respectively). | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 2 | The proliferative activity of QGP-1 cells with PRB expression was also significantly stimulated by the administration of progesterone (p = 0.008). | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 3 | CONCLUSION: The results of the present study demonstrate that PRA could play an inhibitory role in the cell proliferation of PNETs, possibly by inhibiting PRB-mediated signals in the presence of progesterone, which could result in decreased CCND1 expression. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |