Title : Molecular mechanisms of 2, 3', 4, 4', 5-pentachlorobiphenyl-induced thyroid dysfunction in FRTL-5 cells.

Pub. Date : 2015

PMID : 25789747






2 Functional Relationships(s)
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1 Akt, p-Akt, and p-FoxO3a protein or mRNA levels increased significantly in PCB118-treated groups and NIS protein and mRNA levels decreased considerably compared with the control groups. 2,3',4,4',5-pentachlorobiphenyl forkhead box O3 Rattus norvegicus
2 Our results suggested that PCB118 induces thyroid cell dysfunction through the Akt/FoxO3a/NIS signaling pathway. 2,3',4,4',5-pentachlorobiphenyl forkhead box O3 Rattus norvegicus