Pub. Date : 2015 Jun
PMID : 25784721
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salmeterol is a long-acting beta2-adrenergic receptor (beta2AR) agonist that is widely used as a bronchodilator for the treatment of persistent asthma and chronic obstructive pulmonary disease in conjunction with steroids. | Salmeterol Xinafoate | adrenoceptor beta 2 | Homo sapiens |
| 2 | Salmeterol is a long-acting beta2-adrenergic receptor (beta2AR) agonist that is widely used as a bronchodilator for the treatment of persistent asthma and chronic obstructive pulmonary disease in conjunction with steroids. | Salmeterol Xinafoate | adrenoceptor beta 2 | Homo sapiens |
| 3 | Previous studies demonstrated that salmeterol showed weak efficacy for activation of adenylyl cyclase; however, its efficacy in the complex desensitization of the beta2AR remains poorly understood. | Salmeterol Xinafoate | adrenoceptor beta 2 | Homo sapiens |
| 4 | In this work, we provide insights into the roles played by the G protein-coupled receptor kinase/arrestin and protein kinase A in salmeterol-mediated desensitization through bioluminescence resonance energy transfer (BRET) studies of liganded-beta2AR binding to arrestin and through kinetic studies of cAMP turnover. | Salmeterol Xinafoate | adrenoceptor beta 2 | Homo sapiens |
| 5 | First, BRET demonstrated a much reduced efficacy for salmeterol recruitment of arrestin to beta2AR relative to isoproterenol. | Salmeterol Xinafoate | adrenoceptor beta 2 | Homo sapiens |