Title : Inhibition of hepatic drug metabolism by phenothiazine tranquilizers: quantitative structure-activity relationships and selective inhibition of cytochrome P-450 isoform-specific activities.

Pub. Date : 1989 Jul-Aug

PMID : 2577523






1 Functional Relationships(s)
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Protein Name
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1 Derivatives with piperidinyl and piperazinyl ring systems in the 10-position were relatively active inhibitors of P-450 PCN-E (or an immunochemically related form of P-450) that catalyzes androst-4-ene-3,17-dione 6 beta-hydroxylation, and P-450 UT-A-mediated 16 alpha-hydroxylase activity. piperidino cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus