Title : PP2A-B56ϵ complex is involved in dephosphorylation of γ-H2AX in the repair process of CPT-induced DNA double-strand breaks.

Pub. Date : 2015 May 4

PMID : 25772433






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 PP2A-B56epsilon complex is involved in dephosphorylation of gamma-H2AX in the repair process of CPT-induced DNA double-strand breaks. gamma-h2ax protein phosphatase 2 phosphatase activator Homo sapiens
2 Previous study showed that protein phosphatase 2A (PP2A) interact with gamma-H2AX that lead to the dephosphorylation of gamma-H2AX. gamma-h2ax protein phosphatase 2 phosphatase activator Homo sapiens
3 Previous study showed that protein phosphatase 2A (PP2A) interact with gamma-H2AX that lead to the dephosphorylation of gamma-H2AX. gamma-h2ax protein phosphatase 2 phosphatase activator Homo sapiens
4 Notably, we detected that PP2A B56epsilon subunit was involved directly in dephosphorylation of gamma-H2AX and translocated from cytoplasm to nucleus upon the treatment of CPT. gamma-h2ax protein phosphatase 2 phosphatase activator Homo sapiens