Pub. Date : 2015 May
PMID : 25766763
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Imiquimod-induced AMPK activation causes translation attenuation and apoptosis but not autophagy. | Imiquimod | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | OBJECTIVE: To evaluate the role of AMPK in IMQ-induced apoptosis and autophagy. | Imiquimod | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | The role of AMPK activation in IMQ-induced autophagy and apoptosis was assessed by inhibiting AMPK, genetically silencing AMPK and over-expressing AMPK dominant-negative mutants. | Imiquimod | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | The role of AMPK activation in IMQ-induced autophagy and apoptosis was assessed by inhibiting AMPK, genetically silencing AMPK and over-expressing AMPK dominant-negative mutants. | Imiquimod | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | The role of AMPK activation in IMQ-induced autophagy and apoptosis was assessed by inhibiting AMPK, genetically silencing AMPK and over-expressing AMPK dominant-negative mutants. | Imiquimod | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 6 | The role of AMPK activation in IMQ-induced autophagy and apoptosis was assessed by inhibiting AMPK, genetically silencing AMPK and over-expressing AMPK dominant-negative mutants. | Imiquimod | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 7 | IMQ caused ATP depletion and induced LKB1-mediated AMPK activation. | Imiquimod | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 8 | The down-regulation of AMPK activity via pharmacological inhibition and genetic silencing resulted in reduced IMQ-induced apoptosis but did not influence autophagy, and this rescue effect was associated with the retention of translation factor activity and anti-apoptotic Bcl-2 family member Mcl-1 protein expression levels. | Imiquimod | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 9 | CONCLUSION: IMQ induces AMPK activation independent of TLR7/8 expression, resulting in translation inhibition and subsequent apoptosis through ATP depletion and LKB1 signaling, in skin tumor cells. | Imiquimod | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |