Pub. Date : 2015 Aug
PMID : 25762088
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Tizoxanide, the primary active metabolite of the FDA approved drug nitazoxanide, fit in silico pharmacophore models constructed for both mGluR1 and mGluR5. | tizoxanide | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 2 | Subsequent calcium (Ca++) mobilization functional assays confirmed that tizoxanide exhibited appreciable antagonist activity for both mGluR1 and mGluR5 (IC50 = 1.8 muM and 1.2 muM, respectively). | tizoxanide | glutamate receptor, ionotropic, kainate 1 | Mus musculus |